Hemophilic treatment has revolutionized the development of technology that allows the manufacture of recombinant protein on an industrial scale. Blood clotting results from a lack of or deficient protein (factor VIII deficiency) of a Hemophilia A. Hemophilia B bleeds for people longer than others. Dental procedures, minor cuts or trauma may lead to hemorrhages outside of the room or within joints and musculature. In contrast to its plasma-derived counterparts, recombinant coagulation factors have a very low risk of infections, and their use should eliminate the risk of virus infections such as hepatitis C and the human immunodeficiency virus.
Novel Therapeutics Serve to Boost Use of Recombinant Coagulation Factors
Innovative therapy products have also been developed to “bypass” the inhibitor, for example, recombinant active factorVII, licensed for use in hemography for the first time in 1997. Through induction of immunotolerance and by-passing concentrates, hemophilia A treatment with inhibitors enhanced the quality of life in patients, but allowed them not to live as long as they were without inhibitors. ACE910, which simulates FVIII function, seems to reduce bleeding in hemophile A patients with inhibitors with the new humanized monoclonal antibody(MAb) ACE910.
The post-marketing surveillance will clarify whether adverse events in phase III trials and sympathetic use were caused by the combination of a complex concentrate activated by prothrombin or the prothrombotic effect of the drug itself. New products of the second generation for the treatment of inhibitors are actively developing, which is currently the biggest problem with hemophilia management, although there has been considerable progress in the treatment of inhibitors. This is a major demand on the global market for recombinant coagulation factors.
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Rising Incidence of Hemophilia Drives Recombinant Coagulation Factors Market
Increasing numbers of hemophilia patients, increasing diagnostic rates and the increased number of coagulation factors research and development are mainly attributable to this market. In addition, the growth of this market is expected to drive increasing prophylactic treatment for hemophilia worldwide. However, the growth of this market is hampered by high hemophilia costs and availability of cost-effective plasma coagulation factor that could be used in place of recombinant coagulation factors. Recombinant clotting has been widely accepted in the developed world and the coagulation factor supply has increased considerably.
North America to Emerge as Key Regional Market
Increasing demand for quality healthcare is driving the market in North America and increased patients ‘ awareness of various treatment options. As population rises and demand for prompt diagnosis and better global therapy for hemophilia is increasing, recombinant coagulation factors grow on the market. In addition, in the next few years, the global market for recombinant coagulation factors will be growing at a high rate. Increases in development-country medical tourism, increased investment by Asia Pacifical market players, particularly in India and China as well as increasing awareness regarding hemophilia therapy are likely to drive the Asia Pacific market during the projected period.
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Prominent vendors operating in the global recombinant coagulation factors market are Baxter International, Inc., Emergent BioSolutions Inc., Novo Nordisk, and Wyeth.