The gonadotropin-releasing hormone (GnRH) is responsible for the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. The proper functioning of the GnRH is very crucial for the optimum functioning of the reproductive system in females. GnRH analogues (GnRH agonists & antagonists) interact with GnRH receptors in a different way in order to modify the release of hormones for a specified purpose.
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They can be administered through various routes such as intravenous, intramuscular, oral, subcutaneous, and nasal. GnRh agonists are the class of medications that are used in various indications such as fertility treatment, hormone sensitive cancers, endometriosis in women, delaying puberty, and transgender hormone therapy. GnRH antagonists are the medication class that antagonize the action of the GnRH and are used in the treatment of female infertility and cancers. They usually result in the blockage of natural ovulation.
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Increase in government initiatives for birth control measures, increased incidences of prostate cancer among the population, rise in awareness about in-vitro fertilization methods, and increased adoption of GnRH agonists & antagonists are the major factors expected to drive the GnRH agonists & antagonists market. However, high cost of treatment and side effects associated with the treatment are likely to restrain the GnRH agonists & antagonists market. The discovery and development of GnRH antagonists for the treatment of prostate cancer, in order to ensure the effective use of hormone therapy in the treatment of cancer, is an upcoming trend in the GnRH agonists & antagonists market.
Major players operating in the global GnRH agonists & antagonists market include Ferring B.V., Bayer AG, Endo Pharmaceuticals Inc., AbbVie Inc., Contura Ltd., AstraZeneca plc, TerSera Therapeutics LLC, Shire, Informa plc, and Merck KGaA.
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